Gain-of-function research: unproven technique.

COVER Photo of a 1.77-million-year-old complete adult skull (braincase volume: 546 cubic centimeters) of early Homo from the site of Dmanisi, Georgia. Together with the fossilized bones of four additional individuals discovered in close proximity, the skull indicates that populations of early Homo comprised a wider range of morphological variation than traditionally assumed, which implies a single evolving lineage with continuity across continents. See pages 297 and 326.